The null hypothesis value, default is 0 for the normal and the binary case (testing means and rates, respectively), it is 1 for the survival case (testing the hazard ratio).

For non-inferiority designs, thetaH0 is the non-inferiority bound. That is, in case of (one-sided) testing of

• means: a value != 0 (or a value != 1 for testing the mean ratio) can be specified.

• rates: a value != 0 (or a value != 1 for testing the risk ratio pi1 / pi2) can be specified.

• survival data: a bound for testing H0: hazard ratio = thetaH0 != 1 can be specified.

• count data: a bound for testing H0: lambda1 / lambda2 = thetaH0 != 1 can be specified.

For testing a rate in one sample, a value thetaH0 in (0, 1) has to be specified for defining the null hypothesis H0: pi = thetaH0.